The 25th year of The Oprah Winfrey Show will be it’s last according to a spokesperson for Harpo, which Oprah is set to confirm during tomorrow’s show in the US.

Oprah has suggested calling it quits in the past but as her new cable network (OWN – Oprah Winfrey Network) launches in January 2011, the media mogul intends to place her energies there.

Oprah has impacted millions of lives across the world during the last quarter of a century and the final 20 months of the show promises to make history once again before the lights go out on the set.

Oprah makes dreams come true, and next week she is teaming up with Canadian activists Craig and Marc Kielburger to help them achieve their dream of ending poverty and exploitation of children around world. On Monday, May 26, Oprah devotes a full-hour to the the Kielburger brothers and Free The Children founders as they announce their new “O Ambassadors” initiative in association with Oprah’s Angel Network (at 4 p.m. ET).

Before that, CTV explores the Kielburger’s tireless efforts with Free The Children in a one-hour eTalk special (at 10 a.m. ET). Later that day, Degrassi: The Next Generation features a Free The Children storyline (at 7:30 p.m. ET) and a special cameo appearance by Craig Kielburger (visit ctv.ca to confirm local broadcast times).

O Ambassadors, the Free The Children’s joint project with Oprah’s Angel Network, aims to inspire young people to become active and compassionate global citizens. On Monday’s Oprah (4 p.m.), Craig and Marc Kielburger join the talk show host along with more than 350 O Ambassadors from around the world who are already creating ripples of change in their local and global communities.

“The Kielburger’s appearance on Oprah is proof positive of how a local movement can resonate on an international scale,” said Susanne Boyce, President, Creative, Content and Channels, CTV Inc. “These two incredible young Canadians have made a difference in the lives of children worldwide and we are proud to share their story with a national audience.”

In the eTalk Special Event (10 a.m. on May 26; repeating Tuesday, May 27 at 2 p.m. ET), Ben Mulroney and Tanya Kim welcome Craig and Marc Kielburger to the eTalk street front studios on Queen Street in Toronto. Joined by student leaders from across Toronto, cast members from Degrassi: The Next Generation, and webcast submissions from around the world, eTalk honours Free The Children – the world’s largest network of children helping children through education. Montreal correspondent Sophie Grégoire Trudeau engages student leaders on location in Quebec.

More attention is paid to Free The Children when the organization is featured in an all-new episode of Degrassi: The Next Generation at 7:30 p.m. It’s Anya’s (Samantha Munro) first year running the Free The Children Freedom Fast to promote education and health in Africa, and she has a lot to coordinate. Free The Children co-founder Craig Kielburger makes a special cameo appearance.

Oprah Winfrey Presents: Mitch Albom’s For One More Day (Dec. 9 at 9 p.m.)

Oprah Winfrey Presents: Mitch Albom’s For One More Day stars Emmy Award-winning actor Michael Imperioli (The Sopranos), Academy Award-winning actress Ellen Burstyn (Requiem for a Dream, Alice Doesn’t Live Here Anymore) and Vadim Imperioli, Michael Imperioli’s son, in his acting film debut. Michael Imperioli plays Chick Benetto, a broken-down former baseball player who has collapsed into alcoholism and despair. He returns one night to his small hometown with plans to take his life. Suddenly, Chick is magically granted one more day with his departed mother, Posey Benetto (Burstyn) who illuminates the secrets of both their lives and shows him a way to redemption.

Samantha Mathis (The Punisher, American Psycho) plays the younger Posey and Scott Cohen (Law & Order: Trial by Jury, The Return of Jezebel James) plays Chick’s father. Vadim Imperioli, plays the role of the younger Chick.